Reducing Lactate Receptor Stress

Lactate metabolism in human health and disease

Lactate serves not only as an energy metabolite but also as a substrate for energy supply, particularly in neurons where astrocyte-derived lactate supports neuronal energy production. In mood disorders, metabolic dysfunction in the brain, often induced by stress , alters neural activity.

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Understanding lactate sensing and signalling

Lactate transporters and lactate signalling through G protein-coupled receptors (GPCRs) Lactate is transported in a stereospecific manner across plasma membranes.