Cell Function In Type 2

Pancreatic Beta

Pancreatic β- cells produce and secrete insulin to maintain blood glucose levels within a narrow range. Defects in the function and mass of β- cells play a significant role in the development and progression of diabetes. Increased β- cell deficiency and β- cell apoptosis are observed in the pancreatic islets of patients with type 2 diabetes. At an early stage, β- cells adapt to insulin ...

Type 2 diabetes (T2DM) is a complex metabolic disorder manifested by hyperglycemia, insulin resistance, and deteriorating beta- cell function . A way to prevent progression of the disease might be to enhance beta- cell function and insulin secretion.

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In diabetes, glucagon secretion from pancreatic α cells is dysregulated. Dai et al. examined electrical and transcriptomic α cell phenotypes and found that dysfunction in type 2 diabetes is linked to cell maturation state and impaired α cell identity. Notably, a subset of α cells enriched for lineage markers appears uniquely susceptible to dysfunction.

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