1 And Its Receptor Agonist Exendin

Overview of 1 And Its Receptor Agonist Exendin

We have recently shown that cholangiocytes express the Glucagon-Like Peptide-1 receptor (GLP-1R); its activation results in enhanced proliferative reaction to cholestasis. The GLP-1R selective agonist exendin-4 sustains pancreatic β-cell proliferation and prevents cell death by apoptosis.

Key Details About 1 And Its Receptor Agonist Exendin

Glucagon-like peptide-1 (GLP-1), secreted by neuroendocrine cells, sustains β-cell survival in experimental diabetes and induces the neuroendocrine transdifferentiation of pancreatic ductal cells. GLP-1 receptor (GLP-1R) selective agonist exendin-4 is used in humans as a novel therapeutic tool for diabetes.

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This study discovers that the glucagon-like peptide-1 (GLP-1) receptor agonist exendin-4 indirectly inhibits the majority of orexigenic hindbrain NPY neurons via GABAb receptors by augmenting presy...